產(chǎn)品編號 yb-2373R
英文名稱 Anti-Ceruloplasmin抗體
中文名稱 銅藍蛋白抗體
別 名 CER; caeruloplasmin; Ceruloplasmin precursor; CP 2; CP; CP2; CP-2; EC 1.16.3.1; Ferroxidase.
Anti-Ceruloplasmin抗體
說 明 書 0.1ml 0.2ml
研究領(lǐng)域 腫瘤 心血管 細胞生物 免疫學
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse, Rat, Dog, Rabbit,
產(chǎn)品應用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (石蠟切片需做抗原修復)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 120kDa
性 狀 Lyophilized or Liquid
濃 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human Ceruloplasmin
亞 型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed PubMed
產(chǎn)品介紹 background:
Caeruloplasmin is a copper binding plasma glycoprotein consisting of a single polypeptide chain. It has a molecular weight of 132kDa and occurs in plasma at a concentration of 150-500 mg/L. Although the physiological functions of Caeruloplasmin are not fully understood it is implicated in a number of possible functions. 95% of plasma copper is bound to Caeruloplasmin, implying some involvement in copper transport. Caeruloplasmin has been described as both an oxidant and an antioxidant, its exact role or roles in this respect are not clear. Plasma levels of Caeruloplasmin are elevated after inflammation and trauma and it is therefore classified as an acute phase protein. The measurement of Caeruloplasmin in plasma is useful in the diagnosis of Wilson’s disease, where levels are greatly reduced. Caeruloplasmin is extremely labile in plasma and rapidly degrades to 115kDa and 19kDa fragments. The age of plasma samples should therefore be taken into account when interpreting immunological analysis of caeruloplasmin.
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
又稱銅氧化酶,是一種含銅的α2糖蛋白,CER具有氧化酶的活性,起著抗氧化劑的作用。在血循環(huán)中CER的抗氧化活力可以防止組織中脂質(zhì)過氧化物和自由基的生成,特別在炎癥時具有重要意義,也屬于一種急性時相反應蛋白。
銅藍蛋白對多酚及多胺類底物有催化其氧化之能力銅藍蛋白具有遺傳上的基因多形性。其作用為調(diào)節(jié)銅在機體各個部位的分布、合成含銅的酶蛋白.一般認為銅藍蛋白由肝臟合成,一部分由膽道排泄,尿中含量甚微。銅藍蛋白測定對某些肝、膽、腎等疾病的診斷有一定意義。
上海鈺博生物科技有限公司是2012年5月由“海歸”組成的創(chuàng)業(yè)團隊與兩個專業(yè)投資機構(gòu)發(fā)起成立的,以開發(fā)生產(chǎn)科研試劑和特色檢驗產(chǎn)品為方向,經(jīng)過兩年多的努力,已經(jīng)建立了免疫學和分子生物學的五個技術(shù)平臺,開發(fā)了ELISA/ELISpot酶聯(lián)免疫試劑盒、重組蛋白、熒光標記抗體、四聚體(Tetramer)特異性T細胞檢測試劑盒、Aimplex流式高通量多因子檢測、microRNA 表達譜分析和功能研究等系列產(chǎn)品和服務,研究論文在Nature、Eur. J. Immunol、The Journal of Immunology和Arthritis & Rheumatism等學術(shù)期刊上發(fā)表,與國內(nèi)外免疫學、干細胞、傳染病和腫瘤研究及臨床檢驗領(lǐng)域的科學家們建立了良好的合作關(guān)系,形成了一定的品牌影響力。
鈺博生物另建有七大技術(shù)服務平臺(ELISA定制服務,免疫學檢測服務、分子生物學技術(shù)服務、蛋白表達與純化技術(shù)服務、抗體制備技術(shù)服務、細胞培養(yǎng)技術(shù)服務、整體實驗課題服務)并代理國外試劑:abcam 抗體;MBL,eBioscience,BD,R&D,Santan,CST,RayBiotech等品牌試劑,用專業(yè)的知識、專業(yè)的設備、專業(yè)的態(tài)度為客戶提供一站式實驗技術(shù)服務!
我們的優(yōu)勢:完善、穩(wěn)定的實驗體系,優(yōu)秀的科研隊伍,實驗設備、準確可靠的實驗結(jié)果。稟存用戶*的原則,竭誠為您服務。質(zhì)量是所有產(chǎn)品和服務關(guān)鍵的組成部分,我們通過質(zhì)量和實力贏得客戶的信賴。產(chǎn)品的質(zhì)量是企業(yè)的生命。